Drawing upon the remarkable advancements achieved in the treatment of psoriasis and ankylosing spondylitis, our research endeavors are poised for comprehensive exploration into chronic inflammatory diseases, including autoimmune diseases such as rheumatoid arthritis and lupus erythematosus, allergic conditions like allergic asthma, and the formidable challenges such as chronic obstructive pulmonary disease (COPD). Our primary objectives entail unraveling the intricate pathogenesis of these diseases, pinpointing diagnostic and therapeutic targets, and facilitating personalized treatment modalities through meticulous clinical cohort analyses. Moreover, our research agenda encompasses an exhaustive investigation into the genetic underpinnings of these diseases, coupled with in-depth functional studies focusing on selected susceptibility genes. We are committed to delving into the cellular and molecular mechanisms governing immune tolerance, with a view towards shedding new light on the pathogenesis of autoimmune disorders. Furthermore, we aim to advance our understanding of mitigating immune-mediated transplant rejection. Our endeavors also encompass a meticulous examination of the genesis and regulation of pivotal inflammatory effector cells, to usher in novel insights and therapeutic approaches that hold promise for ameliorating the burden of chronic inflammatory diseases.

Our research endeavors are dedicated to conducting comprehensive investigations into the pathogenesis and immunology of emerging infectious diseases, including but not limited to COVID-19, influenza. Our primary aim is to elucidate the immunological mechanisms of these diseases, thereby facilitating the development of indicators for assessing immunity post-infection, which are pivotal for the detection and exploration of novel vaccine strategies. Furthermore, our research initiatives entail in-depth inquiries into both innate and acquired immune responses against infections. We are committed to exploring innovative vaccine carriers and adjuvants, with the goal of enhancing vaccine efficacy, and extends to the study of protective humoral and cellular immune responses, as well as the molecular mechanisms governing immune memory formation and maintenance. Additionally, we seek to investigate individual variations in infection and vaccine responses, along with their determinants, which is crucial for tailoring personalized interventions and optimizing vaccine efficacy across diverse populations. Moreover, our agenda includes a meticulous examination of the formation of chronic infections and the molecular mechanisms underlying immune system depletion. Through these inquiries, we aim to deepen our understanding of persistent infections and their implications for immune health. Furthermore, we endeavor to establish novel animal models, including humanized animal models, to serve as robust tools for studying the human immune response against infections. These models hold promise for advancing our understanding of pathogenesis and immunological mechanism during infection and accelerating the development of effective interventions.