Linrong Lu-SHANGHAI IMMUNE THERAPY INSTITUTE

Research Team

Principal Investigator Adjunct Investigator

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Executive Director

Linrong Lu

Senior Investigator，Shanghai Immune Therapy Institute

Professor, Zhejiang University School of Medicine

Senior Investigator，Shanghai Immune Therapy Institute

Professor, Zhejiang University School of Medicine

linrong_lu@hotmail.com

Dr. Lu is the Executive Director and Senior Investigator of Shanghai Immune Therapy Institute. He is a Distinguished Professor of Shanghai Jiaotong University, Honorary Professor of the University of Edinburgh, Committee Member of the Chinese Society for Cell Biology, Vice President of the Immune Cell Section in the Chinese Society for Cell Biology, Associate Editor of Frontiers in Immunology (T-cell Biology Section), Editorial Board Member of CMI (Cellular and Molecular Immunology) . He has published more than 70 papers in scientific journals including Nature Immunology, Immunity, J. Exp. Med., NAR, PNAS and BLOOD, and has been selected in a number of national talent programmes.

The ICS (Immune Cell Signaling) group led by Dr. Lu focuses on the signalling and regulatory mechanisms during T cell development and differentiation. The laboratory studies the pathogenesis of autoimmune inflammation and autoimmune diseases, as well as the immune effector functions and regulatory mechanisms in anti-viral and anti-tumour immune responses.

Research Areas

T-cell biology, including thymic T-cell development, CD8+ T-cell function,immunological mechanisms and therapeutic strategies for autoimmune diseases and tumours.

Research Direction

1.Development and differentiation of thymic T cells

2.Signal transduction regulation of T cell differentiation

3.CD8+ T-cell subsets and their role in diseases

荣誉奖项

2021年浙江省自然科学一等奖

2018年爱丁堡大学荣誉教授

2012年浙江大学校级先进工作者

2011年浙江大学“五好”研究生导学团队

2010年教育部新世纪优秀人才获得者

2009年浙江省杰出青年基金获得者

科研项目

U21A20199国家自然科学基金区域创新发展联合基金项目胸腺发育障碍和自身免疫炎症导致病理性胸腺萎缩的机制研究 2022年至2025年项目负责人

32100718国家自然科学基金重大专项项目系统性红斑狼疮发病机制及诊疗新策略研究 2022年至2025年课题骨干

31930038 国家自然科学基金重点项目 CTLA-4突变相关自身免疫性疾病的发病机制研究 2020年-2024年项目负责人

科技部重点研发计划基于纳米簇新型材料的生物学效应及其仿生装配复合组织的基础研究 2018年-2020年课题组长

31770954 国家自然科学基金面上项目蛋白质磷酸酶PP2A在Th17细胞分化和炎症性自身免疫性疾病中的作用和机制研究 2018年-2021年项目负责人

31530019 国家自然科学基金重点项目 Msn家族激酶在Th17细胞分化及自身免疫炎症中的功能及机制研究 2016年-2020 年项目负责人

31325009 国家自然科学基金杰出青年基金分子免疫学 2014年-2017年项目负责人

31270927 国家自然科学基金面上项目 TSE3调控T细胞受体信号传导及T淋巴细胞发育的分子机制研究 2013年-2016年项目负责人

31070782 国家自然科学基金面上项目 Rab10对巨噬细胞中TLR4信号传导调控的机制研究 2011年-2013年

30972724 国家自然科学基金面上项目 CD8+调节性T细胞在小鼠自身免疫性脑脊髓炎模型中的治疗作用及机制研究 2010年-2012年

R2090202 浙江省自然科学基金杰出青年团队项目鲁林荣团队 2010年-2012年

30901311 国家自然科学基金青年项目 TSE1基因在T细胞分化发育中的功能及其作用机制研究 2010年-2012年

NIH T32 NRSA Fellowship AI07386 2007年-2008年

Claudia Adams Barr Award Immunoregulation mediated by Qa1 2005年-2006年

教育经历&工作经历

2022.1-至今上海交通大学医学院附属仁济医院、上海市免疫治疗创新研究院执行院长资深研究员

2008.9-至今浙江大学医学院任免疫学研究所教授

2008.1-2009.2 哈佛医学院病理系及Dana-Farber肿瘤研究所研究员

2005.01-2007.12 哈佛医学院病理系及Dana-Farber肿瘤研究所讲师

2001.5-2004.12 哈佛医学院病理系及Dana-Farber肿瘤研究所助理研究员

1998.7-2001.4 麻省理工学院健康科学与技术中心博士后

1993.9-1998.7 中国科学院上海生物化学研究所博士

1988.9-1993.7 中国科学技术大学分子生物学系本科

重要论著

1.Jiang Y, Jin X, Chi Z, Bai Y, Manthiram K, Mudd P, Zhu K, Wang L, Schwartzberg PL, Han Y, Gao X, Lu L*, Xu Q*. Protein phosphatase 2A propels follicular T helper cell development in lupus. J Autoimmun. 2023 Apr;136:103028. doi: 10.1016/j.jaut.2023.103028. 2023 Mar 29. PMID: 37001432.

2.Jin X, Han Y, Wang JQ, Lu L*.CAR-T cell therapy: new hope for systemic lupus erythematosus patients.Cell Mol Immunol. 2021 Dec;18(12):2581-2582. doi: 10.1038/s41423-021-00787-5. 2021 Nov 4.PMID: 34737415

3.Wu L, Xue Z, Jin S, Zhang J, Guo Y, Bai Y, Jin X, Wang C, Wang L, Liu Z, Wang JQ, Lu L* and Liu W*.huARdb: human Antigen Receptor database for interactive clonotype-transcriptome analysis at the single-cell level.Nucleic Acids Res. 2022 Jan 7;50(D1):D1244-D1254. doi: 10.1093/nar/gkab857.7.PMID: 34606616

4.Zhu K, Jin X, Cui Z, Chen S, Wu S, Sloan R, Lin X, Neculai D, Wang D, Hu H, Lu L*.Priming of NLRP3 inflammasome activation by Msn kinase MINK1 in macrophages.Cell Mol Immnol.2021 Oct;18(10):2372-2382. doi: 10.1038/s41423-021-00761-1. Epub 2021 Sep 3.

5.Lu L*.Mobilizing ER IP3 receptors as a mechanism to enhance calcium signaling. Cell Mol Immunol.2021 Sep;18(9):2284-2285.doi: 10.1038/s41423-021-00725-5.Epub 2021 Jul 12.PMID: 34253857

6.Shytikov D, Rohila D, Li D, Wang P, Jiang M, Zhang M, Xu Q, Lu L*.Functional Characterization of Ly49+CD8 T-Cells in Both Normal Condition and During Anti-Viral Response. Front Immunol. 2021 Jan 7;11:602783. doi: 10.3389/fimmu.2020.602783. eCollection 2020.PMID: 33488602

7.Jin X, Xu Q, Pu C, Zhu K, Lu C, Jiang Y, Xiao L, Han Y*, Lu L*. Therapeutic efficacy of anti-CD19 CAR-T cells in a mouse model of systemic lupus erythematosus. Cell Mol Immunol. 2021 Aug;18(8):1896-1903. doi: 10.1038/s41423-020-0472-1. Epub 2020 May 29.PMID: 32472023

8.Lyu J, Wang L, Lu L*. Thymocyte selection: From signaling to epigenetic regulation. Adv Immunol. 2019;144:1-22. doi: 10.1016/bs.ai.2019.08.005. Epub 2019 Oct 15.PMID: 31699214

9.Lyu J, Wang P, Xu T, Shen Y, Cui Z, Zheng M, Fu G, Lu L*. Thymic-specific regulation of TCR signaling by Tespa1. Cell Mol Immunol.2019 Dec;16(12):897-907. doi: 10.1038/s41423-019-0259-4. Epub 2019 Jul 17.PMID: 31316154

10.Zheng M, Li D, Zhao Z, Shytikov D, Xu Q, Jin X, Liang J, Lou J, Wu S, Wang L, Hu H, Zhou Y, Gao X*, Lu L*. Protein phosphatase 2A has an essential role in promoting thymocyte survival during selection. 2019 Jun 18;116(25):12422-12427. doi:10.1073/pnas.1821116116. Epub 2019 May 31.PMID: 31152132

11.Xu Q, Jin X, Zheng M, Rohila D, Fu G, Wen Z, Lou J, Wu S, Sloan R, Wang L, Hu H, Gao X*, Lu L*. Phosphatase PP2A is essential for TH17 differentiation. Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):982-987. doi: 10.1073/pnas.1807484116. Epub 2018 Dec 28.PMID: 30593560

12.Lou J, Li X, Huang W, Liang J, Zheng M, Xu T, Lyu J, Li D, Xu Q, Jin X, Fu G, Wang D, Lu L.* SNX10 promotes phagosome maturation in macrophages and protects mice against Listeria monocytogenes infection. Oncotarget, 2017 Jul 27;8(33):53935-53947. doi: 10.18632/oncotarget.19644. eCollection 2017 Aug 15.PMID: 28903313

13.Liang J, Lyu J, Zhao M, Li D, Zheng M, Fang Y, Zhao F, Lou J, Guo C, Wang L, Wang D, Liu W*, Lu L*. Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors.Nat Commun. 2017 Jun 9;8:15732. doi: 10.1038/ncomms15732.PMID: 28598420

14.Fu G, Xu Q, Qiu Y, Jin X, Xu T, Dong S, Wang J, Ke Y, Hu H, Cao X, Wang D, Cantor H, Gao X and Lu L*. Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1. J Exp Med. 2017 May 1;214(5):1453-1469. doi: 10.1084/jem.20161120. Epub 2017 Apr 11.PMID: 28400474

15.Yue M, Luo D, Yu S, Liu P, Zhou Q, Hu M, Liu Y, Wang S, Huang Q, Niu Y, Lu L*, Hu H*. Misshapen/ NIK-related Kinase (MINK1) is involved in platelet function, hemostasis and thrombus formation. BLOOD. 2016 Feb 18;127(7):927-37. doi: 10.1182/blood-2015-07-659185. Epub 2015 Nov 23.PMID: 26598717

16.Yue Y, Huang W, Liang J, Guo J, Ji J, Yao Y, Zheng M, Cai Z, Lu L*, Wang J*. IL4I1 Is a Novel Regulator of M2 Macrophage Polarization That Can Inhibit T Cell Activation via L-Tryptophan and Arginine Depletion and IL-10 Production. PLoS One. 2015 Nov 24;10(11):e0142979. doi: 10.1371/journal.pone.0142979. eCollection 2015.PMID: 26599209

17.Wang D*, Zheng M, Qiu Y, Guo C, Ji J, Lei L, Zhang X, Liang J, Lou J, Huang W, Dong B, Wu S, Wang J, Ke Y, Cao X, Zhou YT andLu L*, Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell-mediated allergic response. J Exp. Med. 2014 Dec 15;211(13):2635-49. doi: 10.1084/jem.20140470. Epub 2014 Nov 24.PMID: 25422497

18.Lu L* and Wang J*, One way to pathogenesis, many ways to homeostasis. Cellular & Molecular Immunology . 2013 Jan;10(1):2-3. doi: 10.1038/cmi.2012.51. Epub 2012 Oct 29.PMID: 23103722

19.Yao Y, Han W, Liang J, Ji Jian, Wan J, Cantor H, Lu L*, Glatiramer acetate ameliorates inflammatory bowel disease in mice through the induction of Qa-1-restricted CD8+ regulatory cells. Eur. J. Immunol. 2013 Jan;43(1):125-36. doi: 10.1002/eji.201242758. Epub 2012 Nov 7.PMID: 23002042

20.Wang D, Zheng M, Lei L, Ji J, Yao Y, Qiu Y, Ma L, Lou J, Ouyang C, Zhang X, He Y, Chi J, Wang L, Kuang Y, Wang J, Cao X and Lu L*, Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. Nature Immunology .2012 May 6;13(6):560-8. doi: 10.1038/ni.2301.PMID: 22561606

21.Wang D， Lou J, Ouyang C， Chen W， Liu Y， Liu X， Cao X， Wang J and Lu L*, Ras-related Protein Rab10 facilitates TLR4 signaling by promoting replenishment of TLR4 onto the plasma membrane. Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13806-11. doi: 10.1073/pnas.1009428107. Epub 2010 Jul 19.PMID: 20643919

22.Lu L, Kim H-J, Werneck M and Cantor H*, Regulation of CD8+ Treg: Interruption of NKG2A- Qa-1 interaction allows robust suppressive activity and resolution of autoimmune disease. Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19420-5. doi: 10.1073/pnas.0810383105. Epub 2008 Dec 1.PMID: 19047627

23.Lu L and Cantor H*, Generation and Regulation of CD8+ Regulatory T Cells. Cell Mol Immunol. 2008 Dec;5(6):401-6. doi: 10.1038/cmi.2008.50.PMID: 19118505

24.Lu L, Ikizawa K, Hu D, Werneck MBF, Wucherpfennig KW, and Cantor H.*, Regulation of Activated CD4+ T Cells by NK Cells via the Qa-1–NKG2A Inhibitory Pathway. Immunity .2007 May;26(5):593-604. doi: 10.1016/j.immuni.2007.03.017.PMID: 17509909

25.Lu L, Werneck M, Cantor H*. The Immunoregulatory Effects of Qa1. Immunol Rev. 2006 Aug;212:51-9. doi: 10.1111/j.0105-2896.2006.00418.x.PMID: 16903905

26.Lu L, Chen JJ. Molecular cloning and characterization of the promoter of mouse heme-regulated eIF2alpha kinase. Biochim Biophys Acta. 2002 Mar 19;1574(2):193-9. doi: 10.1016/s0167-4781(01)00281-0. PMID: 11955629.

27.Lu L, Han A, Chen J-J*. Translation Initiation Control by Heme-Regulated Eukaryotic Initiation Factor 2alpha Kinase in Erythroid Cells under Cytoplasmic Stresses” Mol. Cell. Biol. 2001 Dec;21(23):7971-80. doi: 10.1128/MCB.21.23.7971-7980.2001.PMID: 11689689

28.*Guan Z, *Lu L, Zhong Z, Liu J, Yu F, Lu S, Xin Y, Liu XY, Hong J, Zhang W*. A spontaneous recurrent seizure-related Rattus NSF gene identified by linker capture subtraction. Mol Brain Res. 2001 Feb 19;87(1):117-23. doi: 10.1016/s0169-328x(00)00286-2.PMID: 11223166

29.Lu L, Zhu J, Zheng Z, Yan M, Xu W, Sun L, Theze J, Liu X*. Jak-STAT pathway is involved in the induction of TNF-b gene during stimulation by IL-2. European Journal of Immunology 1998;28: 805-810.