Chen Dong -SHANGHAI IMMUNE THERAPY INSTITUTE

Research Team

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Founding Director

Chen Dong

Academician, Chinese Academy of Sciences

Senior Investigator, Shanghai Immune Therapy Institute

Chair Professor, School of Medicine and School of Pharmaceutical Sciences, Shanghai Jiao Tong University

Academician, Chinese Academy of Sciences

Director, Shanghai Immune Therapy Institute

Chair Professor, School of Medicine and School of Pharmaceutical Sciences, Shanghai Jiao Tong University

cdonglab@hotmail.com

Dr. Dong has over 200 publications and was rated highly cited researcher for seven times. The honors he has received include the 2009 American Association of Immunologists-BD Bioscience Investigator Award, 2019 International Cytokine and Interferon Society Biolegend-William E. Paul Award, and 2024 Distinguished Fellow of American Association of Immunologists. He is a member of the Chinese Academy of Sciences and a fellow of the American Association for the advancement of Science and the Chinese Academy of Medicine. He is currently co-editor-in-chief for Current Opinion in Immunology and hLife, Editor-in-chief for Frontiers in Immunology- T Cell Biology, Executive Associate Editor for China Sciences- Life Sciences, Associate Editor for Advances in Immunology, and an Editor for Annual Review of Immunology Immunity, and Journal of Experimental Medicine, and a Scientific Advisor for Med.

Research Areas

Dr. Dong’s research is to understand the molecular mechanisms whereby immune and inflammatory responses are normally regulated, and to apply this knowledge to the understanding and treatment of infection, autoimmunity and allergy disorders as well as cancer. The work from Dr. Dong’s group has led to the discoveries of Th17 and T follicular helper (Tfh) cell subsets in the immune system and elucidation of their biological and pathological functions.

Research Direction

1.Mechanisms of differentiation and developmental regulation of helper T(Th) cells

2.Functions and mechanisms of interleukin 17 (IL-17) family proteins in inflammation and tumour immunity.

3.CD8+ T cell depletion and related tumour immune response mechanisms.

荣誉奖项

2023年1月新基石研究员

2021年9月 Nature Reviews Immunology “创刊20年20项免疫学重大突破”入围两项

2020年12月中国医学科学院学部委员

2020年11月科睿唯安“全球高被引科学家”

2020年10月孙思邈肿瘤研究治疗杰出贡献奖

2019年12月国家卫生健康委国际交流与合作中心和西安杨森制药有限公司吴阶平-保罗.杨森医学药学奖（吴杨奖）

2019年11月中国科学院院士

2019年11月吴阶平医学基金会医药创新奖

2019年11月 Web of Sciences（原汤森路透）“全球高被引科学家”

2019年10月国际细胞因子与干扰素协会BioLegend-William. E. Paul细胞因子杰出研究奖

2019年7月北美生物学家协会"Dr. Tsai-Fan Yu Foundation Legacy Award

科研项目

NCI202233, 新基石研究员项目深圳新基石科学基金会 2023年-2027年项目负责人：董晨

2022-I2M-5-01, T细胞在炎症和自身免疫疾病的调控和功能研究中国医学科学院医学与健康科技创新工程-创新单元项目 2022年-2027年项目负责人：董晨

21JC1404200，T细胞调控高亲和力抗体的分子机制研究上海市科委基础重点项目 2021年-2024年项目负责人：董晨

31991170，国家自然科学基金重大项目肿瘤微环境中免疫细胞命运调控机制 2020年-2024年项目负责人：董晨

31821003，炎症生物学与疾病国家自然科学基金创新研究群体项目 2019年-2024年项目负责人：董晨

教育经历&工作经历

2021年4月至今上海市免疫治疗创新研究院，院长

2020年8月至今上海交通大学医学院，教授

2016年9月至2020年8月清华大学医学院, 院长

2014年8月2021年9月清华大学免疫学研究所，所长

2013年3月至今清华大学医学院, 教授

2008年9月至2013年12月美国德克萨斯大学安德森肿瘤中心免疫学系, 终身教授

2004年7月至2008年8月美国德克萨斯大学安德森肿瘤中心免疫学系, 终身副教授

2000年11月至2004年6月美国华盛顿大学（西雅图）免疫学系, 助理教授

1997年4月至2000年11月美国耶鲁大学医学院免疫系, 博士后

1990年8月至1996年8月美国阿拉巴马大学伯明翰分校细胞及分子生物学专业, 博士

1985年9月至1989年7月中国武汉大学细胞生物学, 学士

重要论著

1.Li, Y., Ge, J., Zhao, X., Xu, M., Gou, M., Xie, B., Huang, J., Sun, Q., Sun, L., Bai, X., Tan, S., Wang, X. and Dong, C. Cell autonomous expression of BCL6 is required to maintain lineage identity of mouse CCR6+ ILC3s. Journal of Experimental Medicine. 2023. 220:e20220440.

2.Sun, Q., Zhao, X., Li, R., Liu, D., Pan, B., Xie, B., Chi, X., Cai, D., Wei, P., Xu, W., Wei, K., Zhao, Z., Fu, Y., Ni, L. and Dong, C. STAT3 regulates CD8+ T cell differentiation and functions in cancer and acute infection. Journal of Experimental Medicine. 2023. 220:e20220686.

3.Chi, X., Jin, W., Zhao, X., Xie, T., Shao, J., Bai, X., Jiang, Y., Wang, X., and Dong, C. RORγt expression in mature TH17 cells safeguards their lineage specification by inhibiting conversion to TH2 cells. Sci Adv. 2022. 8: n7774.

4.Liu, X., Hao, J., Wei, P., Zhao, X., Lan, Q., Ni, L., Chen, Y., Bai, X., Ni, L., and Dong, C. SMAD4, activated by the TCR-triggered MEK/ERK signaling pathway, critically regulates CD8(+) T cell cytotoxic function. Sci Adv. 2022. 8: o4577.

5.Feng, H., Zhao, X., Xie, J., Bai, X., Fu, W., Chen, H., Tang, H., Wang, X., and Dong, C. Pathogen-associated T follicular helper cell plasticity is critical in anti-viral immunity. Sci China Life Sci. 2022. 65(6):1075-1090.

6.Wan, S., Ni, L., Zhao, X., Liu, X., Xu, W., Jin, W., Wang, X., and Dong, C. Costimulation molecules differentially regulate the ERK-Zfp831 axis to shape T follicular helper cell differentiation. Immunity. 2021. 54:2740-2755.

7.Ni, L., Cheng, M. L., Feng, Y., Zhao, H., Liu, J., Ye, F., Ye, Q., Zhu, G., Li, X., Wang, P., Shao, J., Deng, Y. Q., Wei, P., Chen, F., Qin, C. F., Wang, G., Li, F., Zeng, H., and Dong, C. Impaired Cellular Immunity to SARS-CoV-2 in Severe COVID-19 Patients. Front Immunol. 2021. 12:603563.

8.Sun, L., Zhao, X., Liu, X., Zhong, B., Tang, H., Jin, W., Clevers, H., Wang, H., Wang, X., and Dong, C. Transcription factor Ascl2 promotes germinal center B cell responses by directly regulating AID transcription. Cell Rep. 2021. 35:109188.

9.Chi, X., Jin, W., Bai, X., Zhao, X., Shao, J., Li, J., Sun, Q., Su, B., Wang, X., Yang, X. O., and Dong, C. RORα is critical for mTORC1 activity in T cell-mediated colitis. Cell Rep. 2021. 36：109682.

10.Dong, C. Defining the TH17 cell lineage. Nat Rev Immunol. 2021. 21(10): 618.

11.Dong, C. Cytokine Regulation and Function in T Cells. Annu Rev Immunol. 2021. 39: 51-76.

12.Huang, J., Lee, H. Y., Zhao, X., Han, J., Su, Y., Sun, Q., Shao, J., Ge, J., Zhao, Y., Bai, X., He, Y., Wang, X., Wang, X. and Dong, C. Interleukin-17D regulates group 3 innate lymphoid cell function through its receptor CD93. Immunity. 2021. 54:673-686.

13.Chang, D., Xing, Q., Su, Y., Zhao, X., Xu, W., Wang, X. and Dong, C. The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation. Immunity. 2020. 53:614-626.

14.Ni, L., Ye, F., Cheng, M.-L., Feng, Y., Deng, Y.-Q., Zhao, H., Wei, P., Ge, J., Gou, M., Li, X., Sun, L., Cao, T., Wang, P., Zhou, C., Zhang, R., Liang, P., Guo, H., Wang, X., Qin, C.-F., Chen, F. and Dong, C. Detection of SARS-CoV-2-specific humoral and celluar immnunity in COVID-19 convalescent individuals.(Report). Immunity. 2020. 52:971-977.

15.Wang, X., Ni, L., Wan, S., Zhao, X., Ding, X., Dejean, A. and Dong, C. Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells. Immunity. 2020. 52:328-341.

16.Xu, W., Zhao, X., Wang, X., Feng, H., Gou, M., Jin, W., Wang, X., Liu, X. and Dong C. The transcription factor Tox2 drives T follicular helper cell development via regulating chromatin accessibility. Immunity. 2019. 51: 826-839

17.Su, Y., Huang, J., Zhao, X., Lu, H., Wang, W., Yang, X. O., Shi, Y., Wang, X., Lai, Y. and Dong, C.Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation. Science Immunology. 2019. 4(36).

18.18.Liu, X., Wang, Y., Lu, H., Li, J., Yan, X., Xiao, M., Hao, J., Hoang, O. N., Khong, H., Chen, T., Huang, R., Wu, J., Zhao, Q., Wu, Q., Xu, S., Wang, X., Jin, W., Yu, S., Wang, Y., Wei, L., Wang, A., Zhong, B., Ni, L., Liu, X., Nurieva, R., Ye, L., Tian, Q., Bian, X.-W. and Dong, C. Genome-wide analysis identifies Nr4a1 as a key mediator of T cell dysfunction. Nature. 2019. 567：525-529

19.Xu, M., Lu, H., Wu, Y., Liu, K., Shi, Y., An, H., Zhang, J., Wang, X., Lai, Y. and Dong, C. An IL-25-mediated autoregulatory circuit in keratinocytes plays a pivotal role in psoriatic skin inflammation. Immunity. 2018. 48：787-798

20.Li, J., Lee, Y., Li, Y., Jiang, Y., Lu, H., Zang, W., Zhao, X., Liu, L., Chen, Y., Tan, H., Yang, Z., Zhang, M. Q., Mak, T. W., Ni, L. and Dong, C. Co-inhibitory molecule B7 superfamily member 1 expressed by tumor-infiltrating myeloid cells induces dysfunction of anti-tumor CD8+ T cells. Immunity. 2018. 48: 773-786