Lei Zhou, Ph.D. -SHANGHAI IMMUNE THERAPY INSTITUTE

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Lei Zhou, Ph.D.

Investigator, Shanghai Immune Therapy Institute

zhoulei@renji.com

Dr. Zhou completed his doctoral research training at the East China Normal University, Institute of Biomedical Sciences, Shanghai Key Laboratory of Regulatory Biology. In 2016, Dr. Zhou joined the Sonnenberg Laboratory at Weill Cornell Medicine for postdoctoral training. In 2018, he was a recipient of a Crohn's & Colitis Foundation Research Fellowship Award. In 2022, Dr. Zhou joined the Shanghai Immune Therapy Institute as a tenure-track assistant professor. The research interest of the Zhou Laboratory is to interrogate the interplay between intestinal microbiota, immune system and enteric nervous system in regulation of mammalian tissue health and disease by employing innovative murine models and novel patient-based studies. His work has been published on Nature, Nature Immunology, he has also been invited to write review or preview for Immunity, Science Immunology and Nature Metabolism.

Research Areas

Mucosal Immunology and Neuroimmunology

Research Direction

1. Innate lymphoid cell regulation of intestinal health and disease

2. Neuroimmune corsstalk at mucosal barrier

荣誉奖项

2022 上海市浦江人才计划

2018-2021 Crohn's & Colitis Foundation Research Fellowship

科研项目

教育经历&工作经历

2022.6-至今上海交通大学医学院附属仁济医院、上海市免疫治疗创新研究院研究员

2016.9-2022.3 美国康奈尔大学医学院博士后

2011.9-2016.6 华东师范大学生命科学学院博士

2007.9-2011.6 西北农林科技大学生命科学学院本科

重要论著

First or co-first author

1.Zhou, L. #, Zhou, W., Joseph, A.M., Chu, C., Putzel, G.G., Fang, B., Teng, F., Lyu, M., et al. (2022). Group 3 innate lymphoid cells produce the growth factor HB-EGF to protect the intestine from TNF-mediated inflammation. Nat Immunol 23, 251-261. (This work was highlighted by Nature Reviews Immunology)

2.Zhou, L. #, Lin, Q., and Sonnenberg, G.F. (2022). Metabolic control of innate lymphoid cells in health and disease. Nat Metab 4, 1650-1659.

3.Zhou, L., and Sonnenberg, G.F. (2020). In Situ Support of ILC Precursors. Immunity 52, 207-209.

4.Zhou, L., Chu, C., Teng, F., Bessman, N.J., Goc, J., Santosa, E.K., Putzel, G.G., Kabata, H., Kelsen, J.R., Baldassano, R.N., et al. (2019). Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2. Nature 568, 405-409. (This work was highlighted by Nature Reviews Immunology)

5.Zhou, L*., Yao, L*., Zhang, Q*., Xie, W., Wang, X., Zhang, H., Xu, J., Lin, Q., Li, Q., Xuan, Y., et al. (2019). REGgamma controls Th17 cell differentiation and autoimmune inflammation by regulating dendritic cells. Cell Mol Immunol 17, 1136-1147.

6.Yao, L.*, Zhou, L.*, Xuan, Y.*, Zhang, P.*, Wang, X., Wang, T., Meng, T., Xue, Y., Ma, X., Shah, A.S., et al. (2019). The proteasome activator REGgamma counteracts immunoproteasome expression and autoimmunity. J Autoimmun 103, 102282.

7.Zhou, L., and Sonnenberg, G.F. (2018). Essential immunologic orchestrators of intestinal homeostasis. Sci Immunol 3.

8.Xu, J.*, Zhou, L.*, Ji, L.*, Chen, F.*, Fortmann, K., Zhang, K., Liu, Q., Li, K., Wang, W., Wang, H., et al. (2016). The REGgamma-proteasome forms a regulatory circuit with IkappaBvarepsilon and NFkappaB in experimental colitis. Nat Commun 7, 10761.

Contributing author (Selected)

1.Zhou, W., Zhou, L., Zhou, J., Bank, J.R.I.L.C., Chu, C., Zhang, C., Sockolow, R.E., Eberl, G., and Sonnenberg, G.F. (2022). ZBTB46 defines and regulates ILC3s that protect the intestine. Nature 609, 159-165.

2.Lyu, M., Suzuki, H., Kang, L., Gaspal, F., Zhou, W., Goc, J., Zhou, L., Zhou, J., Zhang, W., Bank, J.R.I.L.C., et al. (2022). ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut. Nature 610, 744-751.

3.Zhang, W., Lyu, M., Bessman, N.J., Xie, Z., Arifuzzaman, M., Yano, H., Parkhurst, C.N., Chu, C., Zhou, L., Putzel, G.G., et al. (2022). Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection. Cell 185, 4170-4189 e4120.

4.Chu, C., Parkhurst, C.N., Zhang, W., Zhou, L., Yano, H., Arifuzzaman, M., and Artis, D. (2021). The ChAT-acetylcholine pathway promotes group 2 innate lymphoid cell responses and anti-helminth immunity. Sci Immunol 6.

5.Bessman, N.J., Mathieu, J.R.R., Renassia, C., Zhou, L., Fung, T.C., Fernandez, K.C., Austin, C., Moeller, J.B., Zumerle, S., Louis, S., et al. (2020). Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing. Science 368, 186-189.

6.Chu, C., Murdock, M.H., Jing, D., Won, T.H., Chung, H., Kressel, A.M., Tsaava, T., Addorisio, M.E., Putzel, G.G., Zhou, L., et al. (2019). The microbiota regulate neuronal function and fear extinction learning. Nature 574, 543-548.

7.Teng, F., Goc, J., Zhou, L., Chu, C., Shah, M.A., Eberl, G., and Sonnenberg, G.F. (2019). A circadian clock is essential for homeostasis of group 3 innate lymphoid cells in the gut. Sci Immunol 4.