Fan Wu, Ph.D.-SHANGHAI IMMUNE THERAPY INSTITUTE

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Fan Wu, Ph.D.

Investigator, Shanghai Immune Therapy Institute

wufan@renji.com

Dr. Wu is a investigator who focuses on the immunopathogenesis, neutralising antibodies and vaccines for major infectious viral diseases. He has published more than 40 SCI papers in international top academic journals, including Nature, JAMA Internal Med, J Clin Invest, Cell Research, Cell Discovery, etc., with more than 15,000 citations , and has been consecutively selected as one of the "China Highly Cited Scholars" by Elsevier "China Highly Cited Scholars". He has been awarded several talent project grants, such as the National Special Support Programme for High-level Talents, Shanghai Shuguang Scholars, and Shanghai Pujiang Talents.

Research Areas

Viral Infection and Immunity

Research Direction

1. Immunopathogenesis of viral infections.

2.Humoral immune response to viral infections.

3.Development of broad-spectrum neutralising antibody drugs.

荣誉奖项

2022 上海市曙光学者

2021 教育部高等学校科学研究优秀成果奖——自然科学二等奖（第四完成人）

2020-2022 Elsevier “中国高被引学者”

2020 复旦大学抗击新冠肺炎疫情先进个人

2017 上海市浦江人才

科研项目

22SG16，上海市曙光计划，广谱抗冠状病毒中和抗体产生和中和病毒机制研究，2023年1月-2024年12月，项目负责人

2022，国家高层次人才特殊支持计划，项目负责人

2018ZX10301403-002，国家科技部重大专项，多靶点抗高致病性流感病毒的超广谱抗体的应用性研发，2018年1月-2020年12月，课题负责人

2017ZX10202102，国家科技部重大专项，艾滋病功能性治愈策略与临床研究，2017年1月-2020年12月，课题骨干

17PJ408200，上海市浦江人才，恒河猴动物模型研究艾滋病感染过程中和抗体的产生机理，2017年7月-2019年6月，课题负责人

教育经历&工作经历

2022.4-至今上海交通大学医学院附属仁济医院、上海市免疫治疗创新研究院研究员

2017.1-2022.4 复旦大学附属上海市公共卫生临床中心副研究员

2009.10-2016.12 美国国立卫生研究院过敏与传染病研究所博士后

2003.9-2009.7 清华大学生物科学与技术系博士

1999.9-2003.7 武汉大学生命科学学院本科

授权专利

1.ZL202010740319.3. 一种特异性结合冠状病毒的抗体或其抗原结合片段

2.ZL202011061756.9. 冠状病毒的特异性抗体或其抗原结合片段

3.ZL202011061736.1 冠状病毒的中和抗体或其抗原结合片段

4.ZL202011065506.2 冠状病毒的抗体或其抗原结合片段

重要论著

1.Tingting Sun, Yingdan Wang, Peng Zou, Qimin Wang, Jiangyan. Liu, Wanli Liu, Jinghe Huang*, Fan Wu*. M2e specific antibodies protect against influenza PR8 virus in an isotype and route dependent manner. J Med Virol 2023. 95(4):e28721.

2.Yingdan Wang #, Xiang Zhang #, Yunping Ma #, Yanqun Wang #, Wuqiang Zhan, Qinwen Zheng, Meng Zhang, Ping Ji, Mei Liu, Qianying Liu, Tingting Sun, Tongyu Zhu, Yumei Wen, Lei Sun*, Jincun Zhao*, Fan Wu*, Zhenguo Chen*, Jinghe Huang*. Combating the SARS-CoV-2 Omicron (BA.1) and BA.2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies. Cell Discov. 2022 Oct 7;8(1):104

3.Yingdan Wang #, Wuqiang Zhan #, Jiangyan Liu #, Yanqun Wang #, Xiang Zhang, Meng Zhang, Lin Han, Yunping Ma, Lu Lu, Yumei Wen, Zhenguo Chen, Jincun Zhao*, Fan Wu*, Lei Sun*, Jinghe Huang*. A broadly neutralizing antibody against SARS-CoV-2 Omicron variant infection exhibiting a novel trimer dimer conformation in spike protein binding. Cell Res. 2022 Jun 29;1-4

4.Yingdan Wang #, Meiqin Liu #, Yaping Shen #, Yunping Ma #, Xiang Li # , Yuanyuan Zhang #, Mei Liu #, Xing-Lou Yang #, Jun Chen #, Renhong Yan, Die Luan, Yanqun Wang, Ying Chen, Qimin Wang, Haofeng Lin, Yaning Li, Kaiyue Wu, Tongyu Zhu, Jincun Zhao, Hongzhou Lu*, Yumei Wen*, Shibo Jiang*, Fan Wu*, Qiang Zhou*, Zheng-Li Shi*, Jinghe Huang*. Novel sarbecovirus bispecific neutralizing antibodies with exceptional breadth and potency against currently circulating SARS-CoV-2 variants and sarbecoviruses. Cell Discov. 2022; 8: 36

5.Yingdan Wang#, Yunping Ma#, Yan Xu#, Jiangyan Liu#, Xiang Li, Yuyuan Chen, Yan Chen, Jun Xie, Lianbo Xiao, Zheng Xiang*, Fan Wu*, Jinghe Huang*. Resistance of SARS-CoV-2 Omicron variant to convalescent and CoronaVac vaccine plasma. Emerg Microbes Infect. 2022 Dec;11(1):424-427

6.Xiren Deng, Qimin Wang, Mei Liu, Qinwen Zheng, Fan Wu*, Jinghe Huang*. Tetrameric Neuraminidase of Influenza A Virus Is Required to Induce Protective Antibody Responses in Mice. Front Microbiol. 2021 Oct 4;12:729914

7.Fan Wu #, Su Zhao #, Bin Yu #, Yan-Mei Chen #, Wen Wang #, Zhi-Gang Song #, Yi Hu #, Zhao-Wu Tao, Jun-Hua Tian, Yuan-Yuan Pei, Ming-Li Yuan, Yu-Ling Zhang, Fa-Hui Dai, Yi Liu, Qi-Min Wang, Jiao-Jiao Zheng, Lin Xu, Edward C Holmes, Yong-Zhen Zhang*. A new coronavirus associated with human respiratory disease in China. Nature. 2020 Mar;579(7798):265-269.

8.Fan Wu*, Mei Liu, Aojie Wang, Lu Lu, Qimin Wang, Chenjian Gu, Jun Chen, Yang Wu, Shuai Xia, Yun Ling, Yuling Zhang, Jingna Xun, Rong Zhang, Youhua Xie, Shibo Jiang, Tongyu Zhu, Hongzhou Lu, Yumei Wen, Jinghe Huang*. Evaluating the Association of Clinical Characteristics With Neutralizing Antibody Levels in Patients Who Have Recovered From Mild COVID-19 in Shanghai, China. JAMA Intern Med. 2020 Oct 1;180(10):1356-1362

9.Fan Wu*, Ilnour Ourmanov, Andrea Kirmaier, Sivan Leviyang, Celia LaBranche, Jinghe Huang, Sonya Whitted, Kenta Matsuda, David Montefiori, Vanessa M Hirsch*. SIV infection duration largely determines broadening of neutralizing antibody response in macaques. J Clin Invest. 2020 Oct 1;130(10):5413-5424

10.Qimin Wang, Yulin Zhang, Peng Zou, Meixiang Wang, Weihui Fu, Jialei She, Zhigang Song, Jianqing Xu, Jinghe Huang*, Fan Wu* Self-assembly M2e-based peptide nanovaccine confers broad protection against influenza viruses. Front. Microbiol. 2020; 11:1961