Shuo Chen, Ph.D.-SHANGHAI IMMUNE THERAPY INSTITUTE

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Shuo Chen, Ph.D.

Investigator, Shanghai Immune Therapy Institute

shuochen@sjtu.edu.cn

Dr. Chen received his undergraduate degree in Biological Sciences from the School of Life Sciences, Fudan University, and received his PhD in Clinical Medicine from the University of Oxford Medical School, where he studied structural biology of tumour signaling and viruses under the supervision of Yvonne Jones and Dave Stuart, both of whom are Fellows of the Royal Society. Afterwards, he conducted research on tumour suppression in the laboratory of Yvonne Jones and at the Ludwig Institute of Oxford University under the supervision of Royal Society Fellow Xin Lu. He has now returned to China to join the Institute as the Head of the Medical Structural Biology Group.

Research Areas

Structural biology and computational biology research, the main research work includes: molecular biology, cell biology, structural biology, computational biology, including a variety of tools to explore the mechanisms and methods of prevention and treatment of disease.

Research Direction

1. Analysing APL targeted therapeutic solutions from the perspective of structural biology.

2.Development of precise and broad-spectrum targeted anticancer solutions by combining Chinese and Western medicine.

3.Artificial Intelligence (AI) to calculate the structure of cancer drug targets to explore precise anti-cancer drugs.

荣誉奖项

科研项目

21TQ1400226，“基础研究特区计划”项目，PML核体结构与功能的研究，2022年-2026年，项目负责人

高水平地方高校建设项目，中西医结合精准靶向抗癌，2022年-2025年，项目负责人

教育经历&工作经历

2021–至今上海交通大学医学院附属仁济医院、上海市免疫治疗创新研究院、上海市肿瘤研究所研究员

2013–2020 牛津大学医学院路德维格癌症研究所博士后研究员

2011–2012 牛津大学医学院结构生物学中心博士后研究员

2006–2011 牛津大学医学院临床医学专业博士

2002–2006 复旦大学生命科学学院生物科学专业学士

重要论著

1.Shuo Chen; Jia-Le Wu; Ying Liang; Yi-Gang Tang; Hua-Xin Song; Li-Li Wu; Yang-Fei Xing; Ni Yan; Yun-Tong Li; Zheng-Yuan Wang; Shu-Jun Xiao; Xin Lu*; Sai-Juan Chen; Min Lu*; Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site, Cancer Cell, 2021, 39: 225-239

2.Shuo Chen; Jiale Wu; Shan Zhong; Yuntong Li; Ping Zhang; Jingyi Ma; Jingshan Ren; Yun Tan; Yunhao Wang; Kin Fai Au; Christian Siebold; Gareth L. Bond; Zhu Chen*; Min Lu*; E. Yvonne Jones*; Xin Lu*; iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition, Proceedings of the National Academy of Sciences, 2019, 116(35): 17470-17479

3.Shuo Chen*; Doryen Bubeck; Bryan T. MacDonald; Wen-Xue Liang; Jian-Hua Mao; Tomas Malinauskas; Oscar Llorca; A. Radu Aricescu; Christian Siebold; Xi He*; E. Yvonne Jones*; Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling, Developmental Cell, 2011, 21: 848-861

4.Tan Y, Zhang W, Zhu Z, Qiao N, Ling Y, Guo M, Yin T, Fang H, Xu X, Lu G, Zhang P, Yang S, Fu Z, Liang D, Xie Y, Zhang R, Jiang L, Yu S, Lu J, Jiang F, Chen J, Xiao C, Wang S, Chen S, Bian XW, Lu H, Liu F, Chen S. Integrating longitudinal clinical laboratory tests with targeted proteomic and transcriptomic analyses reveal the landscape of host responses in COVID-19. Cell Discov. 2021 Jun 8;7(1):42. 1-19

5.Wang S, Peng Y, Wang R, Jiao S, Wang M, Huang W, Shan C, Jiang W, Li Z, Gu C, Chen B, Hu X, Yao Y, Min J, Zhang H, Chen Y, Gao G, Tang P, Li G, Wang A, Wang L, Zhang J, Chen S, Gui X, Yuan Z, Liu D. Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys. Nat Commun. 2020 Nov 13;11(1):5752. 1-8