Yi Zhong, Ph.D.-SHANGHAI IMMUNE THERAPY INSTITUTE

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Yi Zhong, Ph.D.

Investigator, Shanghai Immune Therapy Institute

zhongyi@sjtu.edu.cn

Dr. Zhong, PI of Renji Hospital/Shanghai Immune Therapy Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China, and PhD supervisor. He is a MARIE-CURIE Scholar of the European Commission's Academy of Cutting-Edge Sciences, and a Shanghai Outstanding Young Academic Leader.He received his PhD degree in Bioinformatics from the University of Tübingen, Germany in 2016. He then worked as a postdoctoral researcher in Immunology at Memorial Sloan Kettering Cancer Center/Howard Hughes Medical Institute, U.S. He joined Renji Hospital, Shanghai Jiaotong University School of Medicine, as a talent recruiting pathway in 2021, and conducts research at the intersection of the frontiers of systems immunology and computational biology. Dr. Zhong has published several important research articles in Nature Immunology (2022), Immunity (2019, 2020), Cell Research (2010, 2011) and Bioinformatics (2017) as the first and corresponding author. The team's research is characterised as cross-disciplinary integration that use cell biology, computational biology, epigenetics, single-cell sequencing technology and other strategies to answer immunological questions. Home: zhong-lab.com

Research Areas

Systems immunology and computational biology. Study of quantitative transcriptional regulation underlying immune cell differentiation in inflammation and tumor environment.

Research Direction

1. Quantitative epigenetic regulation of cell subpopulation dynamics during T-cell differentiation and long-term memory formation.

2. Construction of regulatory maps of T cell spatial and temporal development, and molecular etiology of related clinical diseases.

3. Reconstruction of multilevel transcriptional regulatory network of immune cells and establishment of cell fate prediction model.

荣誉奖项

2021年上海交通大学医学院创新团队成员

2016年欧盟委员会尖端科学院玛丽-居里学者奖

科研项目

1.32170883，国家自然科学基金面上项目，T细胞活化的多层级调控网络及其重塑表观基因组的调控通路，2022年1月-2025年12月，项目负责人

2.2021YFC2301502，国家重点研发计划，基于知识图谱的结核分枝杆菌和冠状病毒长效广谱保护性表位的发现，2021年12月-2024年11月，课题骨干

3.21JC1404200，上海市市科委项目，T细胞调控高亲和力抗体的分子机制研究 2021年10月-2024年9月，项目参与人

4.PITN-GA-2012-316861, Marie Curie Fellowship (EU), Machine Learning for Personalized Medicine, 2013年-2016年, 项目负责人

教育经历&工作经历

2021.4-至今上海交通大学医学院附属仁济医院、上海市免疫治疗创新研究院研究员

2016.4-2021.3 纪念斯隆-凯特林癌症中心博士后

2011.10-2016.3 图宾根大学博士

2009.1-2011.9 中国科学院上海生命科学研究院研究实习员

2007.8-2008.12 上海交通大学医学院病原生物学系科研助理

2004.9-2007.7 上海交通大学医学院硕士

1999.9-2004.7 南华大学预防医学本科

重要论著

1.Yi Zhong, Sarah Walker, Yuri Pritykin, Christina Leslie, Alexander Rudensky, Joris van der Veeken. Hierarchical regulation of the resting and activated T cell epigenome by major transcription factor families. Nature Immunology 2022 Jan;23(1):122-134.

2.Joris van der Veeken*, Ariella Glasner*, Yi Zhong*, Wei Hu, Zhong-Min Wang, Regina Bou-Puerto, Louis-Marie Charbonnier, Talal A Chatila, Christina S Leslie, Alexander Y Rudensky. The transcription factor Foxp3 shapes regulatory T cell identity by tuning the activity of trans-acting itermediaries. Immunity 2020 Nov 17;53(5):971-984.e5.

3.Joris van der Veeken*, Yi Zhong*, Roshan Sharma, Linas Mazutis, Phuong Duo, Dana Pe’er, Christina Leslie, Alexander Rudensky. Natural genetic variation reveals principles of stable epigenetic regulation in virus-specific CD8 T cells. Immunity 2019 May 21;50(5):1202-1217.

4.Yi Zhong#, Theofanis Karaletsos, Philipp Drewe, Vipin T Sreedharan, David Kuo, Kamini Singh, Hans-Guido Wendel, Gunnar Rätsch#. RiboDiff: Detecting changes of mRNA translation efficiency from ribosome footprints. Bioinformatics 2017 Jan 1; 33(1): 139-141.

5.The Cancer Genome Atlas Research Network (TCGA). The molecular taxonomy of primary prostate cancer. Cell 2015 Nov 5;163(4):1011-25.

6.Yi Zhong#, Philipp Drewe, Andrew L Wolfe, Kamini Singh, Hans-Guido Wendel, Gunnar Rätsch. Protein translational control and its contribution to oncogenesis revealed by computational methods. BMC Bioinformatics 2015, 16(Suppl 2):A6.

7.Xiaodi Su*, Yingpu Yu*, Yi Zhong, Eugenia Giannopoulou, Xiaoyu Hu, Hui Liu, Justin Cross, Gunnar Rätsch, Charles Rice, Lionel B. Ivashkiv. Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation. Nature Immunology 2015 Aug;16(8):838-49.

8.Andrew Wolfe*, Kamini Singh*, Yi Zhong, Philipp Drewe, Vinagolu K. Rajasekhar, Viraj R. Sanghvi, Konstantinos J. Mavrakis, Man Jiang, Justine E. Roderick, Joni Van der Meulen, Jonathan H. Schatz, Christina M. Rodrigo, Chunying Zhao, Pieter Rondou, Elisa de Stanchina, Julie Teruya-Feldstein, Michelle A. Kelliher, Frank Speleman, John A. Porco, Jerry Pelletier, Gunnar Rätsch, Hans-Guido Wendel. RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer. Nature 2014 Sep 4;513(7516):65-70.

9.Yi Zhong*, Xiao Chang*, Xing-Jun Cao*, Yan Zhang, Huajun Zheng, Yongzhang Zhu, Chengsong Cai, Yuan-Yuan Li, Guo-Ping, Zhao, Shengyue Wang, Yixue Li, Rong Zeng, Xuan Li, Xiao-Kui Guo. Comparative proteogenomic analysis of the Leptospira interrogans virulence attenuated strain IPAV against the pathogenic strain 56601. Cell Research 2011 Aug;21(8):1210-29.

10.Wei Zhao*, Yi Zhong*, Hua Yuan*, Jin Wang, Huajun Zheng, Ying Wang, Xufeng Cen, Feng Xu, Jie Bai, Xiaobiao Han, Gang Lu, Yongqiang Zhu, Zhihui Shao, Han Yan, Chen Li, Nanqiu Peng, Zilong Zhang, Yunyi Zhang, Wei Lin, Yun Fan, Zhongjun Qin, Yongfei Hu, Baoli Zhu, Shengyue Wang, Xiaoming Ding, Guo-Ping Zhao. Complete genome sequence of the rifamycin SV-producing Amycolatopsis mediterranei U32 revealed its genetic characteristics in phylogeny and metabolism. Cell Research 2010 Oct;20(10):1096-108.