周磊-上海市免疫治疗创新研究院

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研究员

周磊博士

上海市免疫治疗创新研究院-研究员

zhoulei@renji.com

周磊，博士毕业于华东师范大学生命医学研究所，上海市调控生物学重点实验室。2016年前往美国康奈尔大学医学院Greg Sonnenberg实验室开展博士后研究，期间获得克罗恩和结肠炎基金会研究奖学金。2018年，他获得了克罗恩病和结肠炎基金会研究奖学金。2022年加入上海交大医学院附属仁济医院、上海市免疫治疗创新研究院任研究员。课题组主要利用小鼠模型并结合临床样本探究肠道菌群、免疫系统和肠神经系统在哺乳动物组织健康和疾病中的作用，研究成果以第一作者或通讯作者发表在Nature、Nature Immunology等杂志，并应邀在Immunity、Science Immunology和Nature Metabolism杂志撰写综述或评述文章。

研究领域

黏膜免疫和神经免疫

研究方向

1.固有淋巴细胞调控肠道健康和疾病的功能和机制研究

2.黏膜稳态和疾病的神经-免疫调控机制研究

荣誉奖项

2022 上海市浦江人才计划

2018-2021 Crohn's & Colitis Foundation Research Fellowship

科研项目

教育经历&工作经历

2022.6-至今上海交通大学医学院附属仁济医院、上海市免疫治疗创新研究院研究员

2016.9-2022.3 美国康奈尔大学医学院博士后

2011.9-2016.6 华东师范大学生命科学学院博士

2007.9-2011.6 西北农林科技大学生命科学学院本科

重要论著

First or co-first author

1.Zhou, L. #, Zhou, W., Joseph, A.M., Chu, C., Putzel, G.G., Fang, B., Teng, F., Lyu, M., et al. (2022). Group 3 innate lymphoid cells produce the growth factor HB-EGF to protect the intestine from TNF-mediated inflammation. Nat Immunol 23, 251-261. (This work was highlighted by Nature Reviews Immunology)

2.Zhou, L. #, Lin, Q., and Sonnenberg, G.F. (2022). Metabolic control of innate lymphoid cells in health and disease. Nat Metab 4, 1650-1659.

3.Zhou, L., and Sonnenberg, G.F. (2020). In Situ Support of ILC Precursors. Immunity 52, 207-209.

4.Zhou, L., Chu, C., Teng, F., Bessman, N.J., Goc, J., Santosa, E.K., Putzel, G.G., Kabata, H., Kelsen, J.R., Baldassano, R.N., et al. (2019). Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2. Nature 568, 405-409. (This work was highlighted by Nature Reviews Immunology)

5.Zhou, L*., Yao, L*., Zhang, Q*., Xie, W., Wang, X., Zhang, H., Xu, J., Lin, Q., Li, Q., Xuan, Y., et al. (2019). REGgamma controls Th17 cell differentiation and autoimmune inflammation by regulating dendritic cells. Cell Mol Immunol 17, 1136-1147.

6.Yao, L.*, Zhou, L.*, Xuan, Y.*, Zhang, P.*, Wang, X., Wang, T., Meng, T., Xue, Y., Ma, X., Shah, A.S., et al. (2019). The proteasome activator REGgamma counteracts immunoproteasome expression and autoimmunity. J Autoimmun 103, 102282.

7.Zhou, L., and Sonnenberg, G.F. (2018). Essential immunologic orchestrators of intestinal homeostasis. Sci Immunol 3.

8.Xu, J.*, Zhou, L.*, Ji, L.*, Chen, F.*, Fortmann, K., Zhang, K., Liu, Q., Li, K., Wang, W., Wang, H., et al. (2016). The REGgamma-proteasome forms a regulatory circuit with IkappaBvarepsilon and NFkappaB in experimental colitis. Nat Commun 7, 10761.

Contributing author (Selected)

1.Zhou, W., Zhou, L., Zhou, J., Bank, J.R.I.L.C., Chu, C., Zhang, C., Sockolow, R.E., Eberl, G., and Sonnenberg, G.F. (2022). ZBTB46 defines and regulates ILC3s that protect the intestine. Nature 609, 159-165.

2.Lyu, M., Suzuki, H., Kang, L., Gaspal, F., Zhou, W., Goc, J., Zhou, L., Zhou, J., Zhang, W., Bank, J.R.I.L.C., et al. (2022). ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut. Nature 610, 744-751.

3.Zhang, W., Lyu, M., Bessman, N.J., Xie, Z., Arifuzzaman, M., Yano, H., Parkhurst, C.N., Chu, C., Zhou, L., Putzel, G.G., et al. (2022). Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection. Cell 185, 4170-4189 e4120.

4.Chu, C., Parkhurst, C.N., Zhang, W., Zhou, L., Yano, H., Arifuzzaman, M., and Artis, D. (2021). The ChAT-acetylcholine pathway promotes group 2 innate lymphoid cell responses and anti-helminth immunity. Sci Immunol 6.

5.Bessman, N.J., Mathieu, J.R.R., Renassia, C., Zhou, L., Fung, T.C., Fernandez, K.C., Austin, C., Moeller, J.B., Zumerle, S., Louis, S., et al. (2020). Dendritic cell-derived hepcidin sequesters iron from the microbiota to promote mucosal healing. Science 368, 186-189.

6.Chu, C., Murdock, M.H., Jing, D., Won, T.H., Chung, H., Kressel, A.M., Tsaava, T., Addorisio, M.E., Putzel, G.G., Zhou, L., et al. (2019). The microbiota regulate neuronal function and fear extinction learning. Nature 574, 543-548.

7.Teng, F., Goc, J., Zhou, L., Chu, C., Shah, M.A., Eberl, G., and Sonnenberg, G.F. (2019). A circadian clock is essential for homeostasis of group 3 innate lymphoid cells in the gut. Sci Immunol 4.