1. 32441096 国家自然科学基金专项项目 EBV 在狼疮中导致免疫失衡的作用与机制研究，2025-01年至2027-12年 项目负责人

2. 32350007 国家自然科学基金专家推荐类原创探索计划项目 基于抗原特异性鉴定CD8+调节性T细胞的新策略研究 2024-01年至2026-12年 项目负责人

3. U21A20199国家自然科学基金区域创新发展联合基金项目 胸腺发育障碍和自身免疫炎症导致病理性胸腺萎缩的机制研究 2022年至2025年 项目负责人

4. 32100718国家自然科学基金重大专项项目 系统性红斑狼疮发病机制及诊疗新策略研究 2022年至2025年 课题骨干

5. 31930038 国家自然科学基金重点项目 CTLA-4突变相关自身免疫性疾病的发病机制研究 2020年-2024年 项目负责人

6. 科技部重点研发计划 基于纳米簇新型材料的生物学效应及其仿生装配复合组织的基础研究 2018年-2020年 课题组长

7. 31770954 国家自然科学基金面上项目 蛋白质磷酸酶PP2A在Th17细胞分化和炎症性自身免疫性疾病中的作用和机制研究 2018年-2021年 项目负责人

8. 31530019 国家自然科学基金重点项目 Msn家族激酶在Th17细胞分化及自身免疫炎症中的功能及机制研究 2016年-2020 年 项目负责人

9. 31325009 国家自然科学基金杰出青年基金 分子免疫学 2014年-2017年 项目负责人

10. 31270927 国家自然科学基金面上项目 TSE3调控T细胞受体信号传导及T淋巴细胞发育的分子机制研究 2013年-2016年 项目负责人

11. 31070782 国家自然科学基金面上项目 Rab10对巨噬细胞中TLR4信号传导调控的机制研究 2011年-2013年

12. 30972724 国家自然科学基金面上项目 CD8+调节性T细胞在小鼠自身免疫性脑脊髓炎模型中的治疗作用及机制研究 2010年-2012年

13. R2090202 浙江省自然科学基金杰出青年团队项目 鲁林荣团队 2010年-2012年

14. 30901311 国家自然科学基金青年项目 TSE1基因在T细胞分化发育中的功能及其作用机制研究 2010年-2012年

15. NIH T32 NRSA Fellowship AI07386 2007年-2008年

16. Claudia Adams Barr Award Immunoregulation mediated by Qa1 2005年-2006年

2022.1-至今 上海交通大学医学院附属仁济医院、上海市免疫治疗创新研究院 执行院长 资深研究员

2008.9-至今 浙江大学医学院任免疫学研究所 教授

2008.1-2009.2 哈佛医学院病理系及Dana-Farber肿瘤研究所 研究员

2005.01-2007.12 哈佛医学院病理系及Dana-Farber肿瘤研究所 讲师

2001.5-2004.12 哈佛医学院病理系及Dana-Farber肿瘤研究所 助理研究员

1998.7-2001.4 麻省理工学院健康科学与技术中心 博士后

1993.9-1998.7 中国科学院上海生物化学研究所 博士

1988.9-1993.7 中国科学技术大学分子生物学系 本科

1.Protein phosphatase 2A promotes CD8+ T cell effector function through the augment of CD28 co-stimulation. Zhu K*, Rohila D, Zhao Y, Shytikov D, Wu L, Zhao F, Hu S, Xu Q, Jin X* andLu L*.Research2025;8:0545.

2.Integrative Mapping of Human CD8+ T Cell in Inflammation and Cancer. Xue Z, Wu L, Tian R, Gao B, Zhang Y, He B, Sun D, Zhao B, Li Y, Zhu K, Wang L, Yao J*, Liu W*,Lu L*.Nature Methods2025,22, 435-445.

3.GRP75-dependent mitochondria-ER contacts ensure cell survival during early mouse thymocyte development. Zhao F, cui Z, Wang P, Zhao Z, Zhu K, Bai Y, Jin X, Wang L, Lu L*.Dev Cell.59 (19), 2643-2658.

4.Retroviral CRISPR/Cas9-Mediated Gene Targeting for the Study of Th17 Differentiation in Vitro.Cui Z, Yuan P, Zhao Z, Zhao F,Lu L*.J Vis Exp. 2024 Nov 15;(213). doi: 10.3791/66966.

5.Protein phosphatase 2A propels follicular T helper cell development in lupus. Jiang Y, Jin X, Chi Z, Bai Y, Manthiram K, Mudd P, Zhu K, Wang L, Schwartzberg PL, Han Y, Gao X,Lu L*, Xu Q*.J Autoimmun.2023 Mar 29;136:103028.

6.NPAT Supports CD8+ Immature Single-Positive Thymocyte Proliferation and Thymic Development. Cui Z, Zhao F, Chen X, Li J, Jin X, Han Y, Wang L, Zhou Y andLu L*.Journal of Immunology2022 Sep 1, 209 (5): 916-925.

7.Transcriptional Regulation of Early T-Lymphocyte Development in Thymus.Bao X, Qin Y,Lu L*, Zheng M*.Front Immunol.2022 Mar 31;13:884569. doi: 10.3389/fimmu.2022.884569. eCollection 2022.

8.CAR-T cell therapy: new hope for systemic lupus erythematosus patients. Jin X, Han Y, Wang JQ,Lu L*.Cell Mol Immunol.2021 Dec;18(12):2581-2582. doi: 10.1038/s41423-021-00787-5. Epub 2021 Nov 4. (Commentary)

9.huARdb: human Antigen Receptor database for interactive clonotype-transcriptome analysis at the single-cell level. Wu L, Xue Z, Jin S, Zhang J, Guo Y, Bai Y, Jin X, Wang C, Wang L, Liu Z, Wang JQ,Lu L*and Liu W*.Nucleic Acids Res., 2022 Jan 7;50(D1): D1244-D1254. doi: 10.1093/nar/gkab857.

10.Priming of NLRP3 inflammasome activation by Msn kinase MINK1 in macrophages. Zhu K, Jin X, Cui Z, Chen S, Wu S, Sloan R, Lin X, Neculai D, Wang D, Hu H,Lu L*.Cell Mol. Immnol.2021 Oct;18(10):2372-2382. doi: 10.1038/s41423-021-00761-1.

11.Mobilizing ER IP3 receptors as a mechanism to enhance calcium signaling.Lu L*.Cell Mol Immunol.2021 Sep;18(9):2284-2285. doi: 10.1038/s41423-021-00725-5. Epub 2021 Jul 12. (Commentary).

12.Functional Characterization of Ly49+CD8 T-Cells in Both Normal Condition and During Anti-Viral Response.Shytikov D, Rohila D, Li D, Wang P, Jiang M, Zhang M, Xu Q,Lu L*.Front Immunol.2021 Jan 7;11:602783. doi: 10.3389/fimmu.2020.602783. eCollection 2020.

13.Therapeutic efficacy of anti-CD19 CAR-T cells in a mouse model of systemic lupus erythematosus. Jin X, Xu Q, Pu C, Zhu K, Lu C, Jiang Y, Xiao L, Han Y*,Lu L*.Cell Mol Immunol.2021 Aug;18(8):1896-1903. doi: 10.1038/s41423-020-0472-1. Epub 2020 May 29.

14.Thymocyte selection: From signaling to epigenetic regulation. Lyu J, Wang L,Lu L*.Adv Immunol.2019;144:1-22.

15.Thymic-specific regulation of TCR signaling by Tespa1. Lyu J, Wang P, Xu T, Shen Y, Cui Z, Zheng M, Fu G, Lu L.Cell Mol Immunol.2019 Dec;16(12):897-907.

16.Protein phosphatase 2A has an essential role in promoting thymocyte survival during selection. Zheng M, Li D, Zhao Z, Shytikov D, Xu Q, Jin X, Liang J, Lou J, Wu S, Wang L, Hu H, Zhou Y, Gao X*,Lu L*.Proc Natl Acad Sci U S A.2019 Jun 18;116(25):12422-12427.

17.Phosphatase PP2A is essential for TH17 differentiation. Xu Q, Jin X, Zheng M, Rohila D, Fu G, Wen Z, Lou J, Wu S, Sloan R, Wang L, Hu H, Gao X*,Lu L*.Proc Natl Acad Sci U S A.2019 Jan 15;116(3):982-987.

BioCentry Innovations Highlight: https://www.biocentury.com/printpdf/300071

18.SNX10 promotes phagosome maturation in macrophages and protects mice against Listeria monocytogenes infection.Lou J, Li X, Huang W, Liang J, Zheng M, Xu T, Lyu J, Li D, Xu Q, Jin X, Fu G, Wang D,Lu L.*Oncotarget, 2017, 8(33), 53935.

19.Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors. 2017. Liang J, Lyu J, Zhao M, Li D, Zheng M, Fang Y, Zhao F, Lou J, Guo C, Wang L, Wang D, Liu W*,Lu L*. Nature Communications15732 (2017). doi: 10.1038/ ncomms15732

20.Suppression of Th17 cell differentiation by misshapen/NIK-related kinase MINK1. Fu G, Xu Q, Qiu Y, Jin X, Xu T, Dong S, Wang J, Ke Y, Hu H, Cao X, Wang D, Cantor H, Gao X,Lu L*. 14J. Exp. Med.2017 May 1;214(5):1453-1469.

J Exp Med Insights：MINK1： The missing link between ROS and its inhibition of Th17 cells. Martinez GJ. J Exp Med. 2017 May 1;214(5):1205-1206.

21.Misshapen/ NIK-related Kinase (MINK1) is involved in platelet function, hemostasis and thrombus formation. Yue M, Luo D, Yu S, Liu P, Zhou Q, Hu M, Liu Y, Wang S, Huang Q, Niu Y,Lu L*, Hu H*.Blood.2016 Feb;127 (7): 927-37.

22.IL4I1 Is a Novel Regulator of M2 Macrophage Polarization That Can Inhibit T Cell Activation via L-Tryptophan and Arginine Depletion and IL-10 Production. Yue Y, Huang W, Liang J, Guo J, Ji J, Yao Y, Zheng M, Cai Z,Lu L*, Wang J*.PLoS One.2015 Nov 24; 10(11):e0142979.

23.Tespa1 negatively regulates FcεRI-mediated signaling and the mast cell-mediated allergic response. Wang D*, Zheng M, Qiu Y, Guo C, Ji J, Lei L, Zhang X, Liang J, Lou J, Huang W, Dong B, Wu S, Wang J, Ke Y, Cao X, Zhou YT andLu L*,J. Exp. Med.2014 Dec 15;211(13):2635-49.

24.Glatiramer acetate ameliorates inflammatory bowel disease in mice through the induction of Qa-1-restricted CD8+ regulatory cells. Yao Y, Han W, Liang J, Ji Jian, Wan J, Cantor H,Lu L*.Eur. J. Immunol.2013, 43:125-36.

25.One way to pathogenesis, many ways to homeostasis.Lu L*and Wang J*.Cellular & Molecular Immunology2013 10:2-3. (Commentary)

26.Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling. Wang D, Zheng M, Lei L, Ji J, Yao Y, Qiu Y, Ma L, Lou J, Ouyang C, Zhang X, He Y, Chi J, Wang L, Kuang Y, Wang J, Cao X andLu L*.Nature Immunology2012, 13: 560–68.

Nature Immunology News and Views:Tespa1: another gatekeeper for positive selection. by Nicholas R J Gascoigne & Guo Fu Nature Immunology 13,530–532(2012).

Faculty 1000 Article Recommendation:New Finding, Interesting Hypothesis.

27.Ras-related protein Rab10 facilitates TLR4 signaling by promoting replenishment of TLR4 onto the plasma membrane. Wang D， Lou J, Ouyang C， Chen W， Liu Y， Liu X， Cao X， Wang J andLu L*.Proc Natl Acad Sci U S A.2010, 107:13806-11.

28.Regulation of CD8+ Treg: Interruption of NKG2A- Qa-1 interaction allows robust suppressive activity and resolution of autoimmune disease.Lu L, Kim H-J, Werneck M and Cantor H*.Proc Natl Acad Sci U S A.2008 Dec 9;105(49):19420-5.

29.Generation and Regulation of CD8+ Regulatory T Cells.Lu Land Cantor H*.Cell Mol Immunol.2008, 5(6): 401-6.

30.Regulation of Activated CD4+ T Cells by NK Cells via the Qa-1–NKG2A interaction.Lu L, Ikizawa K, Hu D, Werneck MBF, Wucherpfennig KW, and Cantor H.*.Immunity. 2007,25(5): 593-604.

Science News(ScienceDaily, May 18, 2007): Natural Immune-control System May Aid Treatment Of Autoimmune Disease And Tissue Rejection. (Link)

FOCUS(news for Harvard Medical, Dental and Public Health Schools, June 8, 2007): Homegrown Cure for Autoimmune Disease. (Link)

Preview: Immunity, 26(5): 549-551, 25 May 2007 “Good News, Bad News for Missing-Self Recognition by NK Cells: Autoimmune Control but Viral Evasion”, E. Vivier and F. Romagné. (Link)

Research Highlight: Nature Reviews Immunology07, 496-497 (July 2007) “Immune regulation: New regulatory role for NK cells”, Elaine Bell (Link)

31.The Immunoregulatory Effects of Qa1.Lu L, Werneck M, Cantor H*.Immunol Rev.2006;212:51-9.

32.Molecular cloning and identification of the heme-regulated eIF-2a kinase promoter.Lu L, Chen J-J*.Biochem. Biophys. Acta.2002;1574:193-9.

33.Translation Initiation Control by Heme-Regulated Eukaryotic Initiation Factor 2alpha Kinase in Erythroid Cells under Cytoplasmic Stresses.Lu L, Han A, Chen J-J*.Mol. Cell. Biol.2001;21: 7971-7980.

34.A spontaneous recurrent seizure-related Rattus NSF gene identified by linker capture subtraction. Guan Z^#,Lu L#,Zhong Z, Liu J, Yu F, Lu S, Xin Y, Liu XY, Hong J, Zhang W*.Mol Brain Res.2000;87: 117-23. #equal contributors. (Pubmed)

35.ak-STAT pathway is involved in the induction of TNF-b gene during stimulation by IL-2.Lu L, Zhu J, Zheng Z, Yan M, Xu W, Sun L, Theze J, Liu X*.European Journal of Immunology1998;28: 805-810. (Pubmed)