人才队伍
官微平台
资深研究员
Lai Guan Ng 教授
上海市免疫治疗创新研究院-资深研究员
上海市免疫治疗创新研究院-资深研究员
laiguan@me.com
Dr. Ng是澳大利亚Garvan Institute of Medical Research免疫学博士。2009-21年期间在新加坡科技局免疫研究院担任研究员,2022年加入上海市免疫治疗创新研究院,同年获国家海外高层次人才引进计划。Ng实验室主要聚焦于通过在体成像技术、高维流式、多组学以及生物信息学方法研究免疫细胞特别是粒细胞和单核细胞的招募和发育规律,及其在组织稳态和疾病中的作用。作为免疫学界国际知名的学者,Ng教授在髓系细胞领域做了大量开创性工作,在Science,Immunity,J Exp Med等国际顶级期刊发表论文60余篇,被引3万余次,H-index 70+,于2020-24年连续5年荣获 Clarivate“全球高被引学者”。获得国家自然科学基金重大研究计划、重点支持项目、面上项目和上海市科委等多项资助,同时是科技部重点研发计划课题负责人。受邀于Annu Rev Immunol,Nat Rev Immunol,Trends Immunol,Cancer Cell等期刊发表综述和评论。目前任免疫细胞生物学会分会委员、分子免疫专业分会委及中国生理学会血液生理专业委员会委员。曾作为会议召集者主办血液和免疫研讨会大会(2019)、The Granulocyte Meeting (2023)、Keystone symposia (2024)等国际会议。现任Discovery Immunology期刊高级主编、Journal of Leukocyte Biology期刊副主编、Cellular Immunology期刊编和hLife期刊编委。
研究领域
固有免疫,包括髓系细胞在稳态下和病理状态下的功能和机制。
研究方向
1.中性粒细胞和单核细胞的分化机制和迁徙特性
2.中性粒细胞在肿瘤中的异质性
3.中性粒细胞在2型糖尿病中的功能研究
荣誉奖项

2020-2024年 年度论文高被引用科学家(Highly Cited Researcher (Web of Science),2021,2021,2022,2023,2024)

2021年 国家级海外高层次人才引进计划

2018年 年度新加坡科技局“良师益友”奖(The Most Inspiring Mentor (A*STAR),2018)

科研项目

2038669,澳大利亚国家健康与医学研究委员会(NHMRC)创新资助计划,解析肿瘤免疫生态系统的神经调控机制,2025至2029,中方项目负责人

W2431020,国家自然科学基金外国专家项目,中性粒细胞来源的胶原蛋白在肿瘤进展中的作用机制研究,2025-01至2026-12,项目负责人

92374205,国家自然科学基金重大研究计划,综合中性粒细胞多组学数据解锁自身免疫病的生物标志物和治疗靶点,2024-01至2027-12,项目负责人

2023YFC2306302,国家科技部重点研发计划,阐明天然效应分子介导迁徙性细胞捕捉与清除病原体的机制,2024-01至2026-11,课题负责人

2023YFC2506405,国家科技部重点研发计划,阐明免疫新机制推动模型校正与方案优化,2024-01至2026-10,课题骨干

32270956,国家自然科学基金面上项目,肿瘤相关中性粒细胞的异质性研究,2023-01至2026-12,主持

国家科技部,中性粒细胞在糖尿病状态及血糖稳态条件下对创口愈合作用的研究,2022-07至2024-06,主持

H18/01/a0/018,Industry Alignment Fund (Pre-positioning),Cancer lmmunoTherapy Imaging (CITI) Programme: Precision Immune Cell Imaging for Precision Cancer lmmunotherapy,2018-09 至 2023-08,参与

H19/01/a0/024,Industry Alignment Fund (Pre-positioning),SInGapore ImmuNogrAm for Immuno-OncoLogy (SIGNAL),2019-06 至 2023-06,参与

F00021&F00022,新加坡政府项目,SIgN Intramural Core Funding,2010-04 至 2022-03,主持

CMTi-NHIC2/2006,NHG CMTi and National Health Innovation Centre Singapore (NHIC),Joint MedTech Grant Automation of tissue optical clearing processe,2021-03 至 2022-02,参与

H16/01/a0/002,Industry Alignment Fund (Pre-positioning),Humanized NOG Mice for ImmunoTherapy (HuNIT),2017-04 至 2021-04,参与

SIG18027,National Healthcare Group, Skin Innovation Grant, Modulation of biomaterial-mediated wound healing response by biomimetic polymeric surface, 2018-10 至 2020-03, 参与

APP1106439,National Health and Medical Research Council, National Health and Medical Research Council Project Grant,Dynamics and mechanisms of immune complex-mediated skin inflammation,2016-01 至 2019-01,主持

NMRC/CBRG/0084/2015,National Medical Research Council, coorperative basic research grant,Mast cell-driven T cell responses during acute viral infection,2015-07 至 2018-07,参与

SRG/14019,National Healthcare Group, Skin Research Grant,Pathophysiology of itch in atopic dermatitis and psoriasis,2014-08 至 2017-07,主持

SIG/15001,National Healthcare Group, small innovative grant,Genomic Profiling of Type III Hypersensitivity in Cutaneous Vasculitis,2015-07 至 2017-06,主持

新加坡政府项目,Development of cross-platform imaging probes for the study of neutrophil function in vivo,2014-06至2015-05,主持

教育经历&工作经历

2021.12-至今 上海交通大学医学院附属仁济医院、上海市免疫治疗创新研究院 资深研究员

2009.11-2021.12 新加坡科技局免疫研究院 研究员

2007.7-2009.11 悉尼大学 博士后

2006.4-2007.6 威斯塔研究所 博士后

2004.9-2006.3 新加坡科技局分子和细胞生物学研究院 博士后

2001.4-2004.12 新南威尔士大学 免疫学 博士

2000.3-2001.4 新南威尔士大学 药理学 荣誉学士

1997.2-2000.3 悉尼大学 医药科学 本科

重要论著

1. Tommaso Vicanolo#, Alaz Özcan#, Jackson LiangYao Li#, Carla Huerta-López, Iván Ballesteros, Andrea Rubio-Ponce, Andra C Dumitru, Jose Ángel Nicolás-Ávila, Miguel Molina-Moreno, Pablo Reyes-Gutierrez, Andrew D Johnston, Catherine Martone, Eric Greto, Antonio Quílez-Alvarez, Enrique Calvo, Elena Bonzon-Kulichenko, Rebeca Álvarez-Velez, Ming Yao Chooi, Immanuel Kwok, Blanca González-Bermúdez, Benoit Malleret, Francisco M Espinosa, Ming Zhang, Yu-Long Wang, Dasheng Sun, Shu Zhen Chong, Ali El-Armouche, Kevin K Kim, Irina A Udalova, Valentina Greco, Ricardo Garcia, Jesús Vázquez, Ana Dopazo, Gustavo R Plaza, Jorge Alegre-Cebollada, Stefan Uderhardt,Lai Guan Ng*, Andrés Hidalgo*. Matrix-producing neutrophils populate and shield the skin.Nature. 2025; doi: 10.1038/s41586-025-08741-5.

2.Melissa Ng*, Daniela Cerezo-Wallis*,Lai Guan Ng*, Andres Hidalgo*. Adaptations of neutrophils in cancer.Immunity. 2025;58(1):40-58.

3.Lai Guan Ng*, Immanuel Kwok*. Transcending life and death: The ultimate cargo of aged neutrophils.Cell. 2025;188(6):1460-1462.

4. Melissa S F Ng #*, Immanuel Kwok #, Leonard Tan #, Changming Shi #, Daniela Cerezo-Wallis, Yingrou Tan, Keith Leong 1, Gabriel F Calvo, Katharine Yang, Yuning Zhang, Jingsi Jin, Ka Hang Liong 1, Dandan Wu, Rui He, Dehua Liu, Ye Chean Teh, Camille Bleriot, Nicoletta Caronni, Zhaoyuan Liu, Kaibo Duan, Vipin Narang, Iván Ballesteros, Federica Moalli, Mengwei Li, Jinmiao Chen, Yao Liu, Lianxin Liu, Jingjing Qi, Yingbin Liu, Lingxi Jiang, Baiyong Shen, Hui Cheng, Tao Cheng, Veronique Angeli, Ankur Sharma, Yuin-Han Loh, Hong Liang Tey, Shu Zhen Chong, Matteo Iannacone, Renato Ostuni, Andrés Hidalgo, Florent Ginhoux,Lai Guan Ng*. Deterministic reprogramming of neutrophils within tumors.Science. 2024;383(6679):eadf6493.

5. Garett Dunsmore, Wei Guo, Ziyi Li, David Alejandro Bejarano, Rhea Pai, Katharine Yang, Immanuel Kwok, Leonard Tan, Melissa Ng, Carlos De La Calle Fabregat, Aline Yatim, Antoine Bougouin 8, Kevin Mulder, Jake Thomas, Javiera Villar, Mathilde Bied, Benoit Kloeckner, Charles-Antoine Dutertre, Grégoire Gessain, Svetoslav Chakarov, Zhaoyuan Liu, Jean-Yves Scoazec, Ana-Maria Lennon-Dumenil, Thomas Marichal, Catherine Sautès-Fridman, Wolf Herman Fridman, Ankur Sharma, Bing Su, Andreas Schlitzer,Lai Guan Ng*, Camille Blériot*, Florent Ginhoux*.Timing and location dictate monocyte fate and their transition to tumor-associated macrophages,SCIENCE IMMUNOLOGY, 2024, 9(97).

6. Gaofei Li #, Yicong Sun #, Immanuel Kwok, Liting Yang, Wanying Wen, Peixian Huang, Mei Wu, Jing Li, Zhibin Huang, Zhaoyuan Liu, Shuai He, Wan Peng, Jin-Xin Bei, Florent Ginhoux,Lai Guan Ng*, Yiyue Zhang*. Cebp1 and Cebpβ transcriptional axis controls eosinophilopoiesis in zebrafish.Nature Communications. 2024; 15(1):811.

7.Junwen Qu, Jingsi Jin, Ming Zhang,Lai Guan Ng*. Neutrophil diversity and plasticity: Implications for organ transplantation.Cellular & Molecular Immunology, 2023, 20(9): 993-1001.

8.Lai Guan Ng*, Zhaoyuan Liu*, Immanuel Kwok*, Florent Ginhoux*. Origin and Heterogeneity of Tissue Myeloid Cells: A Focus on GMP-Derived Monocytes and Neutrophils.Annu Rev Immunol. 2023;41:375-404.

9. Meiyi Li, Melissa Ng,Lai Guan Ng*. Firing up neutrophil anti-tumor immunity with cocktails.Cancer Cell. 2023;41(2):227-229.

10.I. W. H. Kwok*, E. Becht, Y. Xia, M. Ng, Y. C. Teh, L. Tan, M. Evrard, J. L.Y. Li, H. T. N. Tran, Y. Tan, D. Liu, A. Mishra, K. H. Liong, K. Leong, Y. Zhang, A. Olsson, C. K. Mantri, P. Shyamsunder, Z. Liu, C. Piot, C. A. Dutertre, H. Cheng, S. Bari, N. Ang, S. K. Biswas, H. P. Koeffler, H. L. Tey, A. Larbi, I. H. Su, B. Lee, A. St. John, J. K. Y. Chan, W. Y. K. Hwang, J. Chen, N. Salomonis, S. Z. Chong, H. L. Grimes, B. Liu, A. Hidalgo, E. W. Newell, T. Cheng, F. Ginhoux and L. G. Ng*. 2020. Combinatorial single-cell analyses of granulocyte-monocyte progenitor heterogeneity reveals an early uni-potent neutrophil progenitor Immunity 53:303

11.G. Feng#, J. L. Y. Li#, C. Claser, A. Balachander, Y. Tan, C. C. Goh, I. W. H. Kwok, L. Rénia, B. Z. Tang, L. G. Ng*, B. Liu*. 2018. Dual modal ultra-bright nanodots with aggregation-induced emission and gadolinium-chelation for vascular integrity and leakage detection. Biomaterials 152:77

12.M. Evrard#*, I. W.H. Kwok#, S. Z. Chong, K. W.W. Teng, E. Becht, J. Chen, J. L. Sieow, H. Leong Penny, C. C. Goh, S. Devi, J. M. Adrover, J. L.Y. Li, K. H. Liong, L. Tan, Z. Poon, S. Foo, J. W. Chua, I. H. Su, K. Balabanian, F. Bachelerie, S. K. Biswas, A. Larbi, W. Y.K. Hwang, V. Madan, H. P. Koeffler, S. C. Wong, E. W. Newell, A. Hidalgo, F. Ginhoux, L. G. Ng*. 2018. Developmental analysis of bone marrow neutrophils reveals populations specialized in expansion, trafficking and effector functions. Immunity 48:364

13.Y. Tan#, J. L. Y. Li, B. T. K. Lee, J. Lum, Z. A. D. Pramono, M. Evrard, M. Poidinger, H. L. Tey, L. G. Ng*. 2018. Nanostring analysis of skin biopsies from patients with Henoch-Schönlein Purpura reveals genes associated with pathology and heterogeneity in the disease process. Acta Dermato-Venereologica doi: 10.2340/00015555-2914

14.C. C. Goh#*, M. Evrard, S. Z. Chong, Y. Tan, L. D. L. Tan, K. W. W. Teng, W. Weninger, D. L. Becker, H. L. Tey, E. W. Newell, B. Liu, L. G. Ng*. 2018. The impact of ischemia-reperfusion injuries on skin resident murine dendritic cells. European Journal of Immunology 48:1014

15.Y. Tan Y#, W. J. Ng, S. Z. X. Lee, T. K. Lee, L. A. Nattkemper, G. Yosipovitch, L. G. Ng*, Tey HL*. 2018. Three-dimensional optical clearing and imaging of pruritic atopic dermatitis and psoriasis skin reveals downregulation of epidermal innervation. Journal of Investigative Dermatology 139: 1201

16.J. L. Y. Li#*, C. C. Goh, L. G. Ng*. 2018. Imaging of Inflammatory Responses in the Mouse Ear Skin. Methods Mol Biol 1763:87

17.Y. Tan#*, J. L. Y. Li#*, C. C. Goh, B. T. K. Lee, I. W. H. Kwok, W. J. Ng, M. Evrard, M. Poidinger, H. L. Tey, L. G. Ng*. 2018. Streamlining volumetric multi-channel image cytometry using huesaturation-brightness based surface creation. Communications Biology 1:136

18.R. Bi#, U.S. Dinish, C. C. Goh, T. Imai, M. Moothanchery, X. Li, J. Y. Kim, S. Jeon, Y. Pu, C. Kim, L. G. Ng*, L. V. Wang*, M. Olivo*. 2019. In vivo label-free functional photoacoustic monitoring of ischemic reperfusion. J. Biophotonics doi:10.1002/jbio.201800454

19.Y. Tan#, C. P. L. Chiam, Y. Zhang, H. L. Tey, L. G. Ng*. 2020. Research Techniques Made Simple: Optical Clearing and Three-Dimensional Volumetric Imaging of Skin Biopsies. J Invest Dermatol 140(7):1305

20.Y. Tan#, N. Zhang, Y. Xia, B. T. Lee, L. G. Ng*, H. L. Tey*. 2020. Three-dimensional neuroanatomy of the intraepidermal nervous system. Br J Dermatol doi: 10.1111/bjd.18924

21.I. W. H. Kwok#*, E. Becht, Y. Xia, M. Ng, Y. C. Teh, L. Tan, M. Evrard, J. L.Y. Li, H. T. N. Tran, Y. Tan, D. Liu, A. Mishra, K. H. Liong, K. Leong, Y. Zhang, A. Olsson, C. K. Mantri, P. Shyamsunder, Z. Liu, C. Piot, C. A. Dutertre, H. Cheng, S. Bari, N. Ang, S. K. Biswas, H. P. Koeffler, H. L. Tey, A. Larbi, I. H. Su, B. Lee, A. St. John, J. K. Y. Chan, W. Y. K. Hwang, J. Chen, N. Salomonis, S. Z. Chong, H. L. Grimes, B. Liu, A. Hidalgo, E. W. Newell, T. Cheng, F. Ginhoux and L. G. Ng*. 2020. Combinatorial single-cell analyses of granulocyte-monocyte progenitor heterogeneity reveals an early uni-potent neutrophil progenitor. Immunity 53(2): 303

22.C. Shih#, L. Tan L#, J. L. Y. Li, Tan Y, H. Cheng, L. G. Ng*. Intravital Imaging of Bone Marrow Microenvironment in the Mouse Calvaria and Tibia. 2021. Methods Mol Biol 2308:177

23.Teh#, Y. C., Chooi, M. Y., Liu, D., Kwok, I., Lai, G. C., Ayub Ow Yong, L., Ng, M., Li, J., Tan, Y., Evrard, M., Tan, L., Liong, K. H., Leong, K., Goh, C. C., Chan, A., Shadan, N. B., Mantri, C. K., Hwang, Y. Y., Cheng, H., Cheng, T.,Yu W., Tey H. L, Larbi A., St John A., Angeli V., Ruedl C., Lee B., Ginhoux F., Chen S., Ng L. G.*, Ding J. L.*, Chong, S. Z*. 2022. Transitional premonocytes emerge in the periphery for host defense against bacterial infections. Science advances, 8(9), eabj4641. https://doi.org/10.1126/sciadv.abj4641

24.S. Z. Chong#*, M. Evrard, C. C. Goh, L. G. Ng*. 2017. Illuminating the covert mission of mononuclear phagocytes in their regional niches. Curr Opin Immunol. 50:94

25.L. G. Ng#, R. Otsuni* and A. Hidalgo*. 2019. Heterogeneity of neutrophils. Nat Rev Immunol 19:255

26.L. G. Ng#*. 2019. Neutrophil: a mobile fertilizer. J Exp Med 216:4 (Insights article)

27.L. Yvan-Charvet L#*, L. G. Ng*. 2019. Granulopoiesis and neutrophil homeostasis: A metabolic, daily balancing act. Trends Immunol 40: 598

28.Y. R. Tan#, H. L. Tey, S. Z. Chong*, L. G. Ng*. 2021. Skin-ny deeping: Uncovering immune cell behavior and function through imaging techniques. Immunol Rev: doi: 10.1111/imr.13049

29.M. S. F. Ng#*, L. Tan, Q. Wang, C. R. Mackay, L. G. Ng*. 2021. Neutrophils in cancer-unresolved questions. Sci China Life Sci 64: 1829

30.N. Husna#, N. R. J. Gascoigne, H. L. Tey, L. G. Ng*, Y. Tan*. 2019. Multi-modal image cytometry approach - From dynamic to whole organ imaging. Cell Immunol: doi: 10.1016/j.cellimm.2019.103946

31.Ng L. G#*. 2022. Neutrophils guide pre-existing matrix into injured organs to initiate tissue repair. Nature immunology, 23(4), 472–473. https://doi.org/10.1038/s41590-022-01173-7